Nafcillin, a pencillinaseresistant penicillin, is frequently used for treatment of staphylococcal infections in hemodialysis patients. Identify these minor or nonsignificant nafcillin iv nafcil iv, nallpen iv, unipen iv interactions with the rxlist drug interaction checker tool. We report the use of the continuous infusion of nafcillin for the treatment of an infant who had methicillinsusceptible staphylococcus aureus sternal osteomyelitis not responsive to traditional nafcillin dosing. Nafcillin injection, usp food and drug administration. Learn vocabulary, terms, and more with flashcards, games, and other study tools. See usual adult dose bacterial infection some experts recommend. Nafcillin injection comes as a powder to be mixed with fluid or as a premixed product and injected intravenously into a vein. Two of the cited studies assessed the use of vancomycin among intravenous drug users with endocarditis. Common dose in adults is 2gm iv every 46 hours may be given as a continuous infusion e.
Nafcillin and pediatric dose antibiotics home page. Recommended antimicrobial dosage schedules for neonates. Usual dose is 4 mgkg iv given over 30 min every 24 hr. The standard dosage for children is generally 25 mg per kg about 11.
Nallpen, unipen is an antibiotic in the penicillin group of drugs used to treat many different types of infections, especially those caused by staphylococcus bacteria staph infections. Continuous infusion of nafcillin for sternal osteomyelitis. Pediatric guidelines for iv medication administration. How to use nafcillin sodium vial with threaded port. As an example the iv dose tolerated of taurine is many times over the. Average wholesale prices awp for commonlyused intravenous antibiotics, by dose, per day source. Nafcillin probenecid therapy is generally limited to those infections where very high serum levels of nafcillin are necessary. Nafcillin sodium nafcillin generic is a penicillin antibiotic, prescribed for certain bacterial infections. Nafcillin injection, usp is a sterile injectable product containing nafcillin which is added. Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillinsusceptible staphylococcus aureus bacteremia. Oxacillin oxacillin dose, indications, adverse effects. Nafcillin sodium is a narrowspectrum betalactam antibiotic of the penicillin class.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Nafcillin injection, usp and other antibacterial drugs, nafcillin injection, usp should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When nafcillin and warfarin are used concomitantly, the prothrombin time should be closely monitored and the dose of warfarin adjusted as necessary. Dailymed nafcillin injection, powder, for solution. Nafcillin is given by iv intravenously, as an injection into a vein or as an injection into a muscle an intramuscular, or im, injection two to six times daily. For severe infections, 1 g every 4 hours is recommended. Nafcillin or cefazolin should be considered as the treatment of choice for definitive therapy for mssa.
Hemodialysis does not accelerate nafcillin clearance from the blood. Side effects of nafcillin injection nafcillin sodium. Do not give yourself this medicine if you do not fully understand how to give the injection and properly dispose of used needles, iv tubing, and other items used to inject the medicine. The patient was successfully treated with surgical debridement and the continuous infusion of nafcillin. The nafcillin dosage your healthcare provider uses will depend on the type and severity of the infection, among other factors.
For presumed streptococcal or staphylococcal cellulitis, nafcillin, cephalothin, cefuroxime, vancomycin. A local search option of this data can be found here. Comparative effectiveness of nafcillin or cefazolin versus. Drugs az pill identifier supplements symptom checker diseases dictionary media. Nafcil, nallpen nafcillin dosing, indications, interactions, adverse. Nafcillin side effects, dosage, interactions drugs everyday health. Iv nutrient therapy for the physician 101 why, what and. The implications of osmolality, osmolarity and ph in.
Nafcillin is injected into a muscle, or into a vein through an iv. Nafcillin injection, usp supplied as a premixed frozen solution is to be administered as an intravenous infusion. Dailymed nafcillin nafcillin injection powder, for solution. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Dextrose, usp has been added to the above dosages to adjust osmolality approximately 1. Nafcillin 2 gm q6h is equivalent to oxacillin 2gm q6h. Nafcillin side effects, dosage, interactions drugs. Infusion into a vein can take 30 to 60 minutes to complete. Nafcillin nafcillin dose, indications, adverse effects. Learn about drug interactions between aspirincaffeine oral and nafcillin iv and use the rxlist drug interaction checker to check drug combinations.
Nafcillin is in the penicillin group of antibiotics. Nafcillin injection can also be given intramuscularly into a muscle. Iv nutrient therapy for the physician 101 why, what and how to use this incredible modality. Given as an injection into a vein by iv or a muscle im injection, nafcillin is an antibiotic that is administered two to six times a day. Despite its widespread use, there is a paucity of available data regarding the pharmacokinetics of nafcillin in hemodialysis. A 2 to 5fold increase in warfarin dosage may be required within 2 weeks of starting therapy. Oxacillin is a preferred therapy for penicillinresistant. More severe infections, such as diabetic soft tissue infections, may require 14 to 21 days of therapy. If you are using a dual lumen, drug contact could happen at the catheter tip just as the drugs come in contact with each other. Bactocill oxacillin dosing, indications, interactions. Like cefazolin ancef, nafcillin is a goto drug for treating methicillinsensitive staphylococcus aureus mssa infections infrequently used for nonmssa infections.
Expensive intravenous medications ivs august 2016 this list includes any medication dispensed a minimum of 10 times during the preceding quarter with an average cost per. In addition, during the first 35 days of nafcillin therapy, im or iv gentamicin 3 mgkg. No dosage alterations are necessary for patients with renal dysfunction, including those on hemodialysis. Pediatric guidelines for iv medication administration note. A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication. This medication is given by injection into a vein as directed by your doctor, usually every 4 to 6 hours.
Usual adult dose for skin or soft tissue infection. The fdaapproved dosage for severe infections is 1 g iv every 4 to 6 hours. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020. Because the pediatric dose of nafcillin is based on weight, it is important that your healthcare provider has an accurate weight for your child. The length of your treatment depends on the type of infection you have. Higher doses may be needed for meningitis, though safety and efficacy data for dosing neonates with cns infection are lacking. Like cefazolin ancef, oxacillin is a goto drug for treating methicillinsensitive staphylococcus aureus mssa infections infrequently used for nonmssa infections. Dosing of antimicrobial agents in renal insufficiency. The implications of osmolality, osmolarity and ph in infusion therapy marc stranz, pharmd. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
They list numerous drugs that cannot be added to the same fluid container and others that are incompatible when given at a ysite on the iv set infusing the nafcillin. The usual dosage of nafcillin is 6 to 12 gday, depending on the severity of the. Oxacillin is an alternative therapy for penicillinsusceptible staphylococcal native valve endocarditis nve. Identify these serious nafcillin iv nafcil iv, nallpen iv, unipen iv drug interactions with the rxlist drug interaction checker tool. Alternately, clinical practice guidelines recommend 100 to 150 mgkgday iv divided every 6 to 8 hours for methicillinsensitive s. Nafcillin is given as an infusion into a vein, or injected into a muscle. Nafcillin for injection, usp contains nafcillin sodium as the monohydrate equivalent to 1 gram or 2 grams of nafcillin per vial and is buffered with 40 mg sodium citrate per gram of nafcillin.
Dailymed nafcillin sodium injection, powder, for solution. In a study of five healthy adults administered a single 500 mg dose of nafcillin by intravenous injection over seven minutes, the mean plasma concentration of. Nafcillin iv dose a healthcare provider may prescribe nafcillin for adults and children who have certain bacterial infections. Provides access to the latest drug monographs submitted to the food and drug administration fda. The high end of the dosage should be used for meningitis. As with all penicillins, serious lifethreatening allergic reactions can occur. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. Nafcillin sodium drug information indications, dosage. Nafcillin for oxacillin in all patients lsu school of medicine. This effect may persist for up to 30 days after nafcillin has been discontinued.
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